Science! has indicated that symmetry is both more attractive and easier to process by the human brain.
With this in mind, why do pattern designers helpfully designate the center of the design and add a handy darker line for every ten stitches on the grid on to the pattern to make it easier to count but NOT LINE UP THESE GUIDELINES WITH THE CENTER OF THE PATTERN?!?!?!
I assure you it will be just as neat and satisfying IF NOT MORE SO to have even margins around the edge of the pattern as it is to start with a full ten by ten grid on the top left.
Your design could reap the benefits of sweet creamery cognitive neuroscience!
It's not even like you even start the design in square zero most of the time. If it really freaks you to not have a full grid on the edge just extend the empty part of the graph a little bit! Is it going to mess things up that much to start stitching on column six instead of column two?
I can't show you the grid for this because it is a copyrighted design from BlackBird Designs, but this is the first prep stuff I do for any new piece. I blanket stitch the edges for stability and lay out my pattern space using a counted running stitch every five stitches (aka ten threads since this is a 28ct linen and the design calls for over two stitching, like THAT won't make it more likely for me to mess up).
The white thread designates the dead center of the design while the blue thread designates the graph guidelines already laid over the design to help you count and they are WILDLY out of alignment to each other. The vertical line is off by six stitches (or four depending on your starting point, I guess) and the horizontal is off by five.
I can assure you (*cough* having done it before *cough*) that if I do not clearly mark the orientation of my fabric and separately designate both grids I WILL shift my design over at one point or another, typically early and devastatingly. Taking out an entire day or so of stitching is no fun.
I'm actually considering taking the center markers out entirely on this as soon as I get it on the stretchers to avoid any potential confusion.